I suspect,Tim, you're no great believer in the talking cure, but, come on now, admit it. Doesn't that feel a whole lot better ? Still, I guess feeling better doesn't really count. Not until it's been defined & allotted an agreed & graded index. I can almost hear the firm smack of scientific rigour as your chum's fist drives home into that big palm. As Wystan might have said: Yesterday dopamine & serotonin & 2.beta-isoscrofulanase. But today.... the struggle. Incidentally, you don't want to worry too much about the monoamine oxidase inhibitors. My patients tell me they never noticed any significant lifting of mood until they'd supplemented the damned things with a good square meal of camembert & chianti. But I must collect myself. There's a place & time for levity & this isn't it. Back to JDS & the identification of receptors. Scottie B.